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In a study with subjects with metabolic syndrome, supplementation with 1000 mg/day of curcuminoids and piperine for 8 weeks significantly lowered LDL, non-HDL, total cholesterol, triglycerides and lipoprotein(a) [Lp(a)] and increased HDL (Panahi et al. 2014).

A study tested the effect of daily curcumin extract for 12 weeks on weight, glucose, and lipid profiles in patients with metabolic syndrome. At 12 weeks after the curcumin extract consumption, there was an elevation in the high-density lipoprotein cholesterol level, whereas the level of low-density lipoprotein cholesterol was decreased significantly (Yang et al., 2014).

In another study, curcumin was shown to increase the vascular endothelial function in postmenopausal women, which in turn decreases the risk of cardiovascular diseases (Akazawa et al., 2012).

References:

Akazawa, N., et al. (2012). Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res 32: 795–799.

Panahi, Y., et al. (2014) Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complementary Therapies in Medicine, vol. 22, iss. 5, 851–857.

Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC (2014). Lipid lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res, vol. 28, 1770–1777.