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Peptan® is a natural, high-purity, bioactive product with an impressive protein content of over 97%. Being a Type 1 collagen, Peptan® is identical to the collagen found in human bones and skin.

Manufactured by means of a unique enzymatic hydrolysis process, Peptan® collagen peptides are broken down into smaller peptides that are easy for the body to absorb and put to use. This means they quickly reach the parts of your body where they are most needed – and with maximum effect. 90% of Peptan® collagen peptides are digested and available within the connective tissues just a few hours after digestion.

Peptan® has gained worldwide recognition due to the substantial scientific evidence that backs it up. Its efficacy has been demonstrated in double-blind, placebo-controlled clinical studies and results have been published in leading scientific journals. Peptan® offers benefits in key areas of healthy ageing, skin beauty, joint and bone health and sports nutrition – a holistic solution to support skin beauty and also maintain the health of the musculoskeletal system.

Peptan® is manufactured by Rousselot in state-of-the-art HACCP- and ISO9001-certified plants which meet the highest international food quality standards, and ensure traceability of products and processes. The utmost care is taken in selecting materials as well as raw material suppliers, and submitting them to the strictest quality control programs.

Our Peptan® (derived from bovine hides) is produced in Brazil where the cattle industry is still based on pasture-raised farming – giving Brazilian cattle an important advantage. Our Peptan® is a premium, 100% natural collagen peptide product, sourced predominantly from grass-fed cattle, is safe and free from any preservatives or additives, is certified Halaal, and Kosher-certified at the source.

Peptan® supports healthy cartilage and joint function

Collagen peptides are vital ingredients for healthy joints and bones. In order to maintain healthy joints, our bodies need building blocks that will support tissue regeneration. Collagen peptides are a source of bioactive peptides and act as cellular triggers – this means they actively support healthy cartilage and joint function as well as bone health and strength.

How it works

Human cartilage contains cell called chondrocytes. These produce the extracellular matrix, which consists of collagen and proteoglycans (mainly aggrecan). Collagen fibres (mostly Type II) make up 70-95% of cartilage and are responsible for its structure and strength, while proteoglycans lubricate and cushion our joints. Healthy cartilage relies on a finely balanced process that breaks down collagen and aggrecan and replaces them both with newly-formed matrix. If the process is disturbed, increased matrix breakdown leads to a loss of cartilage and joint function. Peptan® collagen peptides keep this process in balance.

Proven joint benefits of Peptan®:

  • Reducing joint discomfort and stiffness2
  • Acting as a cellular trigger to increase Type II collagen and aggrecan production3
  • Helping to prevent cartilage degeneration and support healthy joints4
  • Uniquely helping to reduce joint inflammation4, a leading cause of joint discomfort

Additional facts highlighted by recent scientific studies:

  • Subjects with the greatest joint deterioration benefited the most from the effects of collagen peptides5,6
  • Healthy athletes with reduced joint discomfort also benefited from collagen peptides when walking, standing or carrying objects7.

As one of the most extensively researched collagen peptides brands available on the market today, Peptan®’s multiple benefits for joint health are well-documented. Here are some highlights from scientific studies.

Peptan® stimulates chondrocytes, boosting the production of type 2 collagen

In an in vitro study3, primary cartilage cells, or chondrocytes, were cultured in the presence of different concentrations of Peptan®. The purpose was to demonstrate Peptan®’s ability to induce the production of the key cartilage components aggrecan and type 2 collagen.

Peptan® treatment clearly stimulated the expression of aggrecan and type 2 collagen by the cartilage cells.

Less discomfort and stiffness with Peptan®

In a clinical trial1, 94 women aged 40 to 70 with knee joint problems received 8g of Peptan® or placebo daily for a period of six months. Peptan® treatment resulted in a statistically significant reduction of the WOMAC score by 24% linked to a 32% decrease in joint pain and a 44% improvement in stiffness.

Protecting cartilage and reducing joint inflammation with Peptan®

An in vivo study4 confirms Peptan® collagen peptides’ role in supporting joint health by providing clear evidence of Peptan®’s ability to protect the cartilage and to reduce inflammation. A visible reduction of cartilage loss in response to osteoarthritis and injury was reported.

The research findings highlight Peptan®’s capacity to preserve cartilage and to stimulate the production of extracellular matrix proteoglycans, which are involved in joint lubrication and cushioning.

A common symptom of joint inflammation is the thickening of the synovial membrane which surrounds the knee. This thickening and the presence of inflammation markers was significantly reduced in the Peptan®-treated groups. These findings have since been presented at international scientific congresses, such as the Annual Meeting of the Orthopaedic Research Society and at the World Congress on Osteoarthritis.

Peptan® for strong, healthy bones

Bones are dynamic, living and growing tissues. Representing around 90% of organic bone mass, collagen is a protein that provides bones with their flexible framework. Calcium phosphate is deposited on this framework, adding strength and stabilising the bone. In other words, collagen and calcium together give our bones their stability, flexibility and stress resistance.

Throughout a person’s lifetime, old bone tissue is broken down and new tissue is added to the skeleton. This process is called bone remodelling, or bone turnover. In healthy adults, bone turnover replaces approximately 15% of our bone per year. As we age, bone breakdown begins to exceed bone formation. Peptan® has been proven to help8,9,10

  • Peptan® helps maintain bone mineral density and thus prevent bone loss
  • Peptan® helps maintain bone strength and a healthy bone micro-architecture
  • Peptan® is efficiently digested (<90%) and absorbed into the bloodstream in the form of small peptides within one hour
  • Peptan® helps balance bone formation and bone breakdown
  • Peptan® actively stimulates bone-building metabolism
  • Peptan® slows down the activity of bone-degrading cells

In a set of in vivo studies8,9 found that a daily intake of Peptan® can restore bone mineral density. The daily intake of Peptan® over a 12-week period was also shown to promote the restoration of bone size and increase bone strength and solidity. A follow-up experiment investigating the preventive effect of Peptan® clearly demonstrated that Peptan® can not only help restore but can also protect against bone loss.

Reference:

  1. Asserin, J., et al. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14:291-301.
  2. Jiang J.X., et al., (2014). Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro FOOD Industry Hi Tech, 25:19-23.
  3. Rousselot unpublished data. (2011)
  4. Dar, Q.A., et al., (2016). Oral hydrolyzed type 1 collagen induces chondroregeneration and inhibits synovial inflammation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 24:S532–S533.
  5. Moskowitz, R. W., (2000). Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30(2):87-99.
  6. Benito-Ruiz, P., et al., (2009). A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60(Sup2):99-113.
  7. Clark, K. L. et al., (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5):1485-1496.
  8. Guillerminet, F. et al., (2010). Collagen peptides improves bone metabolism and biomechanical parameters in ovarietomized mice: an in-vitro and in vivo study. Bone, 46:827-834.
  9. Guillerminet, F. et al., (2012). Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporosis International, 23(7):1909-1919.
  10. Daneault, A. et al., (2014). Hydrolyzed collagen contributes to osteoblast differentiation in vitro and subsequent bone health in vivo. Osteoarthritis and Cartilage, 22:S131.