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Specific Benefits Of Peptan® For Joints And Cartilage

Several in vivo and randomised double-blind placebo-controlled clinical studies have proven multiple benefits that you will not find combined in other joint health supplements.

Peptan® can keep joints healthy by:

  • Reducing joint discomfort and stiffness1
  • Acting as a cellular trigger to increase collagen and aggrecan production2
  • Helping to prevent cartilage degeneration and support healthy joints3
  • Uniquely helping to reduce joint inflammation3, a leading cause of joint discomfort

Additional facts highlighted by recent scientific studies:

  • Subjects with the greatest joint deterioration benefited the most from the effects of collagen peptides4,5
  • Healthy athletes with reduced joint discomfort also benefited from collagen peptides when walking, standing or carrying objects6.

As one of the most extensively researched collagen peptides brands available on the market today, Peptan®’s multiple benefits for joint health are well-documented.

Here are some specific highlights from scientific studies:

Peptan® stimulates chondrocytes, boosting the production of type 2 collagen

In an in vitro study2, primary cartilage cells, or chondrocytes, were cultured in the presence of different concentrations of Peptan®. The purpose was to demonstrate Peptan®’s ability to induce the production of the key cartilage components, aggrecan and type 2 collagen.

Peptan® treatment clearly stimulated the expression of aggrecan and type 2 collagen by the cartilage cells.

Less discomfort and stiffness with Peptan

In a randomised, placebo-controlled, double-blind clinical trial1, 94 women aged 40 to 70 with knee joint problems (osteoarthritis classification: 0-III) received 8g of Peptan® daily for a period of six months.

The WOMAC score (the lower the better) measured joint pain and joint function in daily life, while the Lysholm score (the higher the better) evaluated knee joint function when limping, walking, jumping and stair climbing.

Peptan® treatment resulted in a statistically significant reduction of the WOMAC score by 24% linked to a 32% decrease in joint pain and a 44% improvement in stiffness.

Peptan® treatment also resulted in a statistically significant increase of the Lysholm score by 7%, which demonstrates the improvements over time.

Protecting cartilage and reducing joint inflammation with Peptan®

A new in vivo study confirms Peptan® collagen peptides’ role in supporting joint health by providing clear evidence of Peptan®’s ability to protect the cartilage and to reduce inflammation in mice3. Reporting a visible reduction of cartilage loss in response to osteoarthritis and injury, the research findings highlight Peptan®’s ability to preserve cartilage and to stimulate the production of extracellular matrix proteoglycans, which are involved in joint lubrication and cushioning.

A common symptom of joint inflammation is the thickening of the synovial membrane which surrounds the knee. This thickening and the presence of inflammation markers was significantly reduced in the Peptan®-treated groups. These findings have been presented at international scientific congresses, such as the Annual Meeting of the Orthopaedic Research Society and at the World Congress on Osteoarthritis.


1. Jiang J.X. et al., 2014, Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro FOOD Industry Hi Tech, 25:19-23

2. Rousselot unpublished data, 2011

3. Dar Q.A. et al., 2016, Oral hydrolyzed type 1 collagen induces chondroregeneration and inhibits synovial inflammation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 24:S532–S533

4. Moskowitz, R. W., 2000, Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30(2):87-99

5. Benito-Ruiz, P. et al., 2009, A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60(Sup2):99-113

6. Clark, K. L. et al., 2008, 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5):1485-1496

Collagen And Cellulite

Long-term therapy with orally administered collagen peptides leads to an improvement of cellulite.

Cellulite is a complex problem that affects about 85% of women over the age of 20. It occurs mainly on the thighs, buttocks, and abdomen and is characterized by orange peel or cottage cheese appearance.

Factors linked to cellulite include genetics, gender, age, ethnicity, diet, sedentary lifestyle, and pregnancy. It is characterised by the presence of excess subcutaneous fat that bulges into the dermis, blood, and lymphatic disturbances and altered dermal extracellular matrix.

Although cellulite is often present in healthy individuals of normal weight, it is exacerbated by being overweight.

It is known that the improvements of dermal strength and skin elasticity are two important therapeutic aims in cellulite treatment. An oral therapy with bioactive collagen peptides is based on the premise that specific collagen peptides can improve and increase dermal firmness and skin elasticity from the inside.

In a double-blind, placebo-controlled clinical study, the efficacy of bioactive collagen peptides on the cellulite treatment of normal and overweight women was investigated.

The results of the study demonstrated that a regular ingestion of collagen peptides over a period of 6 months led to a clear improvement of the skin appearance in women suffering from moderate cellulite. Based on the current data, it can be concluded that a long-term therapy with orally administered collagen peptides leads to an improvement of cellulite and has a positive impact on skin health.


Schunck, M. et al. (2015). Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. Journal of Medicinal Food, vol. 18, pp. 1340–1348.

Positive Effect of Peptan®

Peptan® Scientific Evidence

Peptan® is scientifically proven to:

Skin Beauty

  • support skin health
  • improve skin hydration
  • increase dermal density
  • reduce skin wrinkles
  • reduce visibility of pores
  • increase the strength of hair

Supplementation with 5g of Peptan daily for 90 days:

  • 13% reduction in wrinkles around the eyes
  • 10% reduction in wrinkles around the mouth
  • 13% increase in the strength of hair

Supplementation with 10g of Peptan daily for 90 days significantly increased skin hydration by as much as 28% after eight weeks of intake. Peptan helps counteract the appearance of dry skin typical in aging by increasing the skin's moisture levels.

In a study done using human skin samples, Peptan treatment stimulated the production of hyaluronic acid. Peptan helps improve the skin's moisture by increasing the amount of water-binding hyaluronic acid in the epidermis.

Collagen Peptides for Skin Beauty and Hair Health

Peptan® collagen peptides go beyond just helping smooth wrinkles. Adding further evidence to Peptan’s strong scientific portfolio, a new clinical study revealed that supplementation with Peptan significantly contributes to improving the overall appearance of skin and hair in an ethnically diverse population.

Sitting underneath the skin’s outer epidermis layer, our dermis gives skin strength and firmness. As people age, the dermis changes structure because its collagen network breaks up and thins. At the same time skin fibroblast cells slow down production of the matrix that surrounds them, and degraded matrix components are not replaced fast enough. This leads to loss of skin elasticity, hydration and strength, causing visible sagging and wrinkle formation.

Thanks to the remarkable properties of collagen peptides, and their specific bioactivity, studies in humans have shown that Peptan collagen peptides improve skin hydration and dermal collagen density, reducing fragmentation of the dermal collagen network1, helping to reduce the signs of aging.

This new clinical study provides powerful evidence that supplementation with Peptan (Type 1) collagen peptides reduces skin pore visibility and strengthens hair2.

The randomized, double-blind, placebo-controlled study was conducted with 60 healthy Brazilian women, aged 45 to 60 years. During a set period of 90 days, participants received a 5g daily dose of Peptan collagen peptides from bovine origin. Results showed significant improvements in the overall appearance of the skin;

  • A decrease in periorbital wrinkles (around the eyes) by 13% and nasolabial wrinkles (from bottom of the nose to the corners of the mouth) by 10% and
  • A reduction of the visibility of pores in the region of the cheekbones in 57% of the Peptan-supplemented participants.

An increase of the density of the dermis, which contains the strength-providing collagen layer of the skin, following Peptan supplementation, was at the basis of these observations.

This study also revealed a 13% increase in the mechanical strength of hair. (Mechanical strength is linked to improved properties of the hair cortex, which can be especially beneficial for aging hair).

Conducted in a Brazilian population of mixed skin and hair types, this study brings proof that Peptan is effective across populations of different ethnical backgrounds, adding to previous evidence obtained from trials in Caucasian and Asian populations. 


  1. Asserin, J., et al. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, vol. 14, pp. 291—301. [Available at:]
  2. Prawitt, Dr. J., Scientific Director, Peptan®. (June 2019). Whitepaper, Collagen Peptides for Skin Beauty and Hair Health, Rousselot, The Netherlands. [Available at:]

Hydrolysed Collagen and Vitamins Improve Skin Elasticity and Density

UV radiation (from the sun or artificial sources), poor nutrition and other environmental factors, as well as physiological aging, all cause a decrease in the levels of collagen in the body. This leads to a decrease in the skin’s thickness and firmness, and loss of elasticity and hydration.

A healthy lifestyle, including the right nutrition (food and supplements containing vitamins and antioxidants), can help us feel better and look better, too. Nutricosmetics are skincare supplements that deliver their nutrients internally, rather than topically, to generate “beauty from within”.

Collagen is essential for proper maintenance of skin health, and in the arena of ingestible beauty products, collagen has long been recognized as the star player. Given the trends to complement topical treatments with oral supplements, the presented study provides scientific evidence of the benefits of hydrolysed collagen peptides with vitamins and antioxidants, as a functional food, for the skin.

In a randomized, double-blind, placebo-controlled study, the effect of oral supplementation with hydrolysed collagen and vitamins A, C, E and zinc, on skin elasticity, density and firmness of the facial skin was examined. Healthy females ranging in age from 40 to 60 years took a daily supplement of 10g collagen peptides with vitamins for 90 days.

The antioxidants used in the study (vitamins A, C, E & zinc), provide protection from free radical damage and inflammation, which have a negative effect on collagen synthesis. In addition, Vitamin C is essential in collagen synthesis (it promotes the hydroxylation of the amino acids proline and lysine into hydroxyproline and hydroxylysine.)

Treatment with collagen peptides and vitamins (antioxidants) for 90 days resulted in the following effects:

  • Increase in skin hydration
  • Increase in skin elasticity
  • Visible reduction in the depth of wrinkles and fine lines
  • Improvement in the structure (thickness) of the dermis
  • Visible reduction in the size and number of pores in 81% of the those who took the hydrolysed collagen and vitamin product

72% of the group receiving a placebo presented with a visible increase in the size and number of pores during the 90 days study period.

This study showed that a hydrolysed collagen based oral supplement with vitamins and antioxidants is effective in the overall improvement in aged skin conditions.


Campos, P., et al. (2015). An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clinical Pharmacology & Biopharmaceutics, vol. 4, issue 3, pp. 2 – 6. [Available at:]